九州大学大学院　医学研究院　形態機能病理学

DEPARTMENT OF ANATOMIC PATHOLOGY, PATHOLOGCAL SCIENCES, GRADUATE SCHOOL OF MEDICAL SCIENCES, KYUSHU UNIVERSITY

ホーム研究・業績浸潤性膵管癌における癌関連線維芽細胞中のポドプラニン発現

浸潤性膵管癌における癌関連線維芽細胞中のポドプラニン発現

胆道・膵臓グループ

研究内容

2015年12月13日公開　2015年12月13日更新

癌細胞とその周囲に存在する癌関連線維芽細胞（cancer-associated fibroblasts、以降CAFs）との相互作用は、癌進展に重要な役割を持っている。膵臓の浸潤性膵管癌は、豊富な線維性結合組織（デスモプラジア）を特徴とする。様々な種類の癌腫において、ポドプラニンが間質のCAFsに発現することが予後因子と報告されている。我々は、膵癌組織や細胞株を用いて実験を行い、その結果、ポドプラニン陽性CAFsは膵臓浸潤性膵管癌の進展を促進し、ポドプラニン陽性CAFsが高率であることは術後の独立した予後不良因子であることが分かった。

参考文献：

  • Mizuuchi Y, Aishima S, Ohuchida K, Shindo K, Fujino M, Hattori M, Miyazaki T, Mizumoto K, Tanaka M, Oda Y.Anterior gradient 2 downregulation is mediated by epithelial mesenchymal transition and correlates with poor outcome in pancreatic ductal adenocarcinoma. Lab Invst, 2015 Feb;95(2):193-206.
  • Oda Y, Aishima S, Morimatsu K, Shindo K, Fujino M, Mizuuchi Y, Hattori M, Miyazaki T, Tanaka M, Oda Y. Pancreatic intraepithelial neoplasia in the background of invasive ductal carcinoma of the pancreas as a prognostic factor. Histopathology. 2014 Sep;65(3):389-97.
  • Shindo K, Aishima S, Ohuchida K, Fujino M, Mizuuchi Y, Hattori M, Ohtsuka T, Tokunaga S, Mizumoto K, Tanaka M. Oda Y. Podoplanin expression in the cyst wall correlates with the progression of intraductal papillary mucinous neoplasm. Virchows Arch. 2014 Sep;465(3):265-73.
  • Shindo K, Aishima S, Ohuchida K, Fujiwara K, Fujino M, Mizuuchi Y, Hattori M, Mizumoto K, Tanaka M, Oda Y. Podoplanin expression in cancer-associated fibroblasts enhances tumor progression of invasive ductal carcinoma of the pancreas. Mol Cancer. 2013 Dec;12(1):168.
  • Morimatsu K, Aishima S, Yamamoto H, Hayashi A, Nakata K, Oda Y, Shindo K, Fujino M, Tanaka M, Oda Y. Insulin-like growth factor II messenger RNA-binding protein-3 is a valuable diagnostic and prognostic marker of intraductal papillary mucinous neoplasm. Hum Pathol. 2013 Sep;44(9):1714-21.
  • Oda Y, Aishima S, Morimatsu K, Hayashi A, Shindo K, Fujino M, Mizuuchi Y, Hattori M, Tanaka M, Oda Y. Differential ezrin and phosphorylated ezrin expression profiles between pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasm, and invasive ductal carcinoma of the pancreas. Hum Pathol. 2013 Aug;44(8):1487-98.
  • Morimatsu K, Aishima S, Kayashima T, hayashi A, Nakata K, Oda Y, Taguchi T, Tsuneyoshi M, Tanaka M, Oda Y. Liver-Intestine Cadherin Expression Is ssociated with Intestinal Differentiation and Carcinogenesis in Intraductal Papillary Mucinous Neoplasm. Pathobioligy. 2012 Feb;79(2):107-14.
  • Nakata K, Nagai E, Ohuchida K, Hayashi A, Miyasaka Y, Aishima S, Oda Y, Mizumoto K, Tanaka M, Tsuneyoshi M. S100P is a novel marker to identify intraductal papillary mucinous neoplasms. Hum Pathol. 2010;41:824-31.
  • Hayashi A, Aishima S, Inoue T, Nakata K, Morimatsu K, Nagai E, Oda Y, Tanaka M, Tsuneyoshi M. Decreased expression of focal adhesion kinase is associated with a poor prognosis in extrahepatic bile duct carcinoma. Hum Pathol. 2010;41:859-66.
  • Hayashi A, Aishima S, Miyasaka Y, Nakata K, Morimatsu K, Oda Y, Nagai E, Oda Y, Tanaka M, Tsuneyoshi M. Pdcd4 expression in intraductal papillary mucinous neoplasm of the pancreas: its association with tumor progression and proliferation. Hum Pathol. 2010;41:1507-15.
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